Abstract

Background: Immunoglobulin E (IgE) plays a central role in allergic responses and is often elevated in individuals with allergic diseases such as asthma, rhinitis, and eczema. Monitoring serum IgE lev els can provide insights into the efficacy of interventions targeting allergic inflammation. Objective: This study aimed to evaluate the effectiveness of an 8-week intervention in reducing serum IgE levels among individuals with elevated IgE. Methods: A quantitative pre-experimental design was employed, involving repeated measurements of serum IgE at five time points: before intervention (week 0), and at weeks 2, 4, 6, and 8. Serum IgE levels were analyzed using standardized immunoassay techniques. Descriptive statistics were used to report mean values and standard deviations. Results: The results showed a con sistent and progressive reduction in serum IgE levels over time. The mean IgE level prior to interven tion was 350 IU/mL (±45.2), which decreased to 290 IU/mL (±42.8) at week 2, 220 IU/mL (±40.1) at week 4, 150 IU/mL (±35.5) at week 6, and 98 IU/mL (±30.3) at the end of week 8. This downward trend indicates the potential effectiveness of the intervention in suppressing IgE-mediated immune responses. Conclusion: The 8-week intervention demonstrated a significant reduction in serum IgE levels, suggest ing its potential benefit in managing allergic conditions. Further randomized controlled trials with larger samples are recommended to confirm these findings and explore underlying immunological mechanisms.

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