Abstract

Background: In aerobic organisms, oxygen metabolism produces Reactive Oxygen and Nitrogen Spe cies (ROS/RONS) as byproducts. Within certain quantities they act as mediators and stimulators of vi tal functions but when their generation overreaches the cellular antioxidant defense, they react against important biomolecules and led to Oxidative Stress (OS), affecting organs and important functions. OS affects liver, the resulted dysfunctions also affect other organs, increasing cardiovascular risk (CVR).

Methods: Using blood analysis, we followed the effects of induced OS on the organ functions of stressed mice and their recovery by antioxidant nutritional therapy with probiotics (yeast, selenized yeast, vitamin B12 and cranberry). We also evaluated the evolution of liver and cardiovascular func tions in young men predisposed to liver, cardiovascular, kidney and diabetes diseases, combining a diet supplemented with probiotics and physical training. In stressed mice probiotic complement ed diet resulted in better defense and recovery to OS. In individuals, nutritional therapy combined physical activities helped improve liver and cardiovascular function parameters. The combined nu tritional and training strategy in young individuals allows to prevent fatty liver disease and CVR.

Conclusions: OS is the most important pathogenic cause in liver diseases, and it’s well correlated with cardiovascular risks and other organic dysfunctions.

DOI: doi.org/10.63721/25JPMHC0104

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